1,2-Dichloroethane → HCID 22034100, compound

HRID 1792285Notes

Reaction equation

HRID 1792285 reaction equation
[CH3:1][C:2]1[C:3]([O:14][C:15]2[C:20]([CH3:21])=[CH:19][C:18]([CH3:22])=[CH:17][C:16]=2[CH3:23])=[N:4][C:5]([CH3:13])=[CH:6][C:7]=1[NH:8][CH2:9][CH2:10][NH:11]C.[CH3:24][O:25][C:26]1[CH:27]=[C:28]([CH2:34][C:35]([OH:37])=O)[CH:29]=[CH:30][C:31]=1[O:32][CH3:33].C(Cl)CCl.C1C=CC2N(O)N=NC=2C=1>CN(C=O)C.CCOC(C)=O>[CH3:24][O:25][C:26]1[CH:27]=[C:28]([CH2:34][C:35]([NH:11][CH2:10][CH2:9][NH:8][C:7]2[CH:6]=[C:5]([CH3:13])[N:4]=[C:3]([O:14][C:15]3[C:20]([CH3:21])=[CH:19][C:18]([CH3:22])=[CH:17][C:16]=3[CH3:23])[C:2]=2[CH3:1])=[O:37])[CH:29]=[CH:30][C:31]=1[O:32][CH3:33]

Participants

7

Reactant 4

HCID 111,2-DichloroethaneHCID 7139(3,4-Dimethoxyphenyl)acetic acidHCID 757711-HydroxybenzotriazoleHCID 22034134HCID 22034134, compound

Product 1

HCID 22034100HCID 22034100, compound

Reagents, catalysts & solvents 2

HCID 6228DimethylformamideSolventHCID 8857Ethyl AcetateSolvent

Procedure

Stir a solution of [3,6-dimethyl-2-(2,4,6-trimethyl-phenoxy)-4-pyridyl][2-(methylamino)ethyl]amine (68 mg, 0.23 mmol), 3,4-dimethoxyphenylacetic acid (59 mg, 0.3 mmol), EDC (59 mg, 0.3 mmol) and HOBT (41 mg, 0.3 mmol) in DMF (1.0 mL) for 12 h. Dilute the reaction mixture with EtOAc (10 mL) and wash with saturated aq NaHCO3 (2×10 mL) and saturated aq brine (2×10 mL), dry and concentrate in vacuo to obtain the title compound as an oily residue. M+1: 478.

Workup

  1. washwash with saturated aq NaHCO3 (2×10 mL) and saturated aq brine (2×10 mL)
  2. customdry
  3. concentrationconcentrate in vacuo

Sources & evidence

ORD record
ord-f213b349498040b1b9d7ad3b03a50bd3
Source dataset
uspto-grants-2006_07
Patent number
US07074929B2

Reaction notes

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