反应详情

温度

100 °C

To a solution of 2-hydroxybenzaldehyde (2.30 g, 18.8 mmol) in DMF (20 mL) is added 1-(chloromethyl)-naphthalene (3.36 mL, 22.6 mmol) and K2CO3 (3.11 g, 22.6 mmol), and the reaction mixture is heated to 100° C. for 12 h. Once complete, the reaction mixture is cooled to room temperature and diluted with water (100 mL) prior to being poured into a separatory funnel containing ethyl acetate (250 mL). The organic layer is separated, washed with brine (2×) and dried over sodium sulfate prior to concentration. The crude product is purified by column chromatography (5% ethyl acetate in hexanes) to afford 2-(1-naphthylmethoxy)benzaldehyde (2.13 g, 43%) as a light yellow oil.

1. temperatureOnce complete, the reaction mixture is cooled to room temperature
2. additionto being poured into a separatory funnel
3. customThe organic layer is separated
4. washwashed with brine (2×)
5. dry with materialdried over sodium sulfate
6. concentrationto concentration
7. customThe crude product is purified by column chromatography (5% ethyl acetate in hexanes)