Phenylhydrazine → HCID 178515184, compound

HRID 1797891Notes

Reaction equation

HRID 1797891 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[N:5]=[CH:4][C:3]=1[C:12]([O:14]CC)=O.C(N(CC)CC)C.[C:24]1([NH:30][NH2:31])[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1>CC1C=CC=CC=1C>[C:24]1([N:30]2[C:12](=[O:14])[C:3]3=[CH:4][NH:5][C:6]4[CH:7]=[CH:8][CH:9]=[CH:10][C:11]=4[C:2]3=[N:31]2)[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1

Participants

5

Reactant 3

HCID 7516PhenylhydrazineHCID 8471TriethylamineHCID 268963Ethyl 4-Chloroquinoline-3-carboxylate

Product 1

HCID 178515184HCID 178515184, compound

Reagents, catalysts & solvents 1

HCID 7237O-XyleneSolvent

Procedure

A suspension of ethyl 4-chloro-quinoline-3-carboxylate (3a) (2.35 g, 0.01 M) in 20 mL of o-xylene was refluxed with triethylamine (2.0 mL, 0.02 M) and phenyl hydrazine (2.89 g, 0.02 M) overnight. The crude product was obtained by filtration followed by washing the solid with cold methanol.

Sources & evidence

ORD record
ord-8ed176e5daa64842ae9a0ff5a8253e0e
Source dataset
uspto-grants-2013_01
Patent number
US08343957B2

Reaction notes

Loading…