Benzyl Bromide → 1-Bromo-4-phenylmethoxybenzene

HRID 1816859Notes

Reaction equation

HRID 1816859 reaction equation
[CH:1]1[C:6]([OH:7])=[CH:5][CH:4]=[C:3]([Br:8])[CH:2]=1.[CH2:9](Br)[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1>CN(C=O)C>[CH2:9]([O:7][C:6]1[CH:5]=[CH:4][C:3]([Br:8])=[CH:2][CH:1]=1)[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1

Participants

4

Reactant 2

HCID 7498Benzyl BromideHCID 78084-Bromophenol

Product 1

HCID 1388351-Bromo-4-phenylmethoxybenzene

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
80 °C

Procedure

To a solution composed of p-bromophenol (17.3 g, 0.1 mol) and dry DMF (100 mL), anhydride K2CO3 (8.28 g, 0.06 mmol) and benzyl bromide (25.6 g, 0.15 mmol) were added. The mixture was stirred at 80° C. under a nitrogen atmosphere for six hours. Then, the reaction mixture was charged into 500 mL of ice water.

Workup

  1. additionwere added

Sources & evidence

ORD record
ord-5e11c941b17046ef94b03835ee80a6cd
Source dataset
uspto-grants-2009_10
Patent number
US07597980B2

Reaction notes

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