反应详情

To a solution of tert-butyl 2-(4-formylphenyl)ethylcarbamate (3.0 g, 12.0 mmol), 2-methylpyrrolidine (1.44 ml, 14.4 mmol) and acetic acid (1.4 ml, 24.0 mmol) in THF (100 ml) was added sodium triacetoxyborohydride (5.1 g, 24.0 mmol), and the mixture was stirred at room temperature for 16 hrs. 10% Sodium hydrogencarbonate solution (100 ml) was added to the reaction solution, and the mixture was extracted with ethyl acetate (200 ml). The extract was washed with saturated brine, and dried over magnesium sulfate, and solvent was evaporated under reduced pressure. The residue was purified by alumina column chromatography (developing solvent; hexane:ethyl acetate=4:1) to give the title compound (3.10 g).

1. extractionthe mixture was extracted with ethyl acetate (200 ml)
2. washThe extract was washed with saturated brine
3. dry with materialdried over magnesium sulfate, and solvent
4. customwas evaporated under reduced pressure
5. customThe residue was purified by alumina column chromatography (developing solvent; hexane:ethyl acetate=4:1)