2-Bromopropane → HCID 68683337, compound

HRID 1820552Notes

Reaction equation

HRID 1820552 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:21]([N:23]2[CH2:28][CH2:27][N:26]([CH:29]([CH3:31])[CH3:30])[CH2:25][CH2:24]2)=[O:22])[CH:5]=[C:6]2[C:10]=1[NH:9][C:8]([C:11]([N:13]1[CH2:18][CH2:17][C:16]([F:20])([F:19])[CH2:15][CH2:14]1)=[O:12])=[CH:7]2.[H-].[Na+].Br[CH:35]([CH3:37])[CH3:36]>CN(C)C=O>[Cl:1][C:2]1[CH:3]=[C:4]([C:21]([N:23]2[CH2:28][CH2:27][N:26]([CH:29]([CH3:31])[CH3:30])[CH2:25][CH2:24]2)=[O:22])[CH:5]=[C:6]2[C:10]=1[N:9]([CH:35]([CH3:37])[CH3:36])[C:8]([C:11]([N:13]1[CH2:18][CH2:17][C:16]([F:20])([F:19])[CH2:15][CH2:14]1)=[O:12])=[CH:7]2

Participants

5

Reactant 3

HCID 63582-BromopropaneHCID 24758Sodium hydrideHCID 68681372HCID 68681372, compound

Product 1

HCID 68683337HCID 68683337, compoundYield 24%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

The title compound was synthesized in analogy to example 51, from [7-chloro-2-(4,4-difluoro-piperidine-1-carbonyl)-1H-indol-5-yl]-(4-isopropyl-piperazin-1-yl)-methanone (example 232), sodium hydride and 2-bromopropane in N,N-dimethylformamide, to give the desired product as a colorless foam (24%).

Sources & evidence

ORD record
ord-8237751939a5455fb414c2b137123450
Source dataset
uspto-grants-2009_10
Patent number
US07601711B2

Reaction notes

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