Iodoethane → HCID 10256039, compound

HRID 1821966Notes

Reaction equation

HRID 1821966 reaction equation
[Cl:1][C:2]1[CH:23]=[C:22]([O:24][CH2:25][CH:26]=[C:27]([Cl:29])[Cl:28])[CH:21]=[C:20]([Cl:30])[C:3]=1[O:4][CH2:5][CH2:6][CH2:7][O:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[N:16]=[N:17][NH:18][N:19]=2)=[CH:11][CH:10]=1.[CH2:31](I)[CH3:32].C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O>[Cl:30][C:20]1[CH:21]=[C:22]([O:24][CH2:25][CH:26]=[C:27]([Cl:29])[Cl:28])[CH:23]=[C:2]([Cl:1])[C:3]=1[O:4][CH2:5][CH2:6][CH2:7][O:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[N:16]=[N:17][N:18]([CH2:31][CH3:32])[N:19]=2)=[CH:11][CH:10]=1

Participants

5

Reactant 3

HCID 6340IodoethaneHCID 11430Potassium CarbonateHCID 10074301HCID 10074301, compound

Product 1

HCID 10256039HCID 10256039, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

100 mg of 5-(4-{3-[2,6-dichloro-4-(3,3-dichloro-allyloxy)-phenoxy]-propoxy}-phenyl)-2H-tetrazole, 48 mg of ethyl iodide and 141 mg of potassium carbonate are stirred for 4 hours at 50° C. in 3 ml of dimethylformamide. The reaction mixture is poured onto water and extracted with ethyl acetate. Concentration of the organic phase and purification over silica gel yield 5-(4-{3-[2,6-dichloro-4-(3,3-dichloro-allyloxy)-phenoxy]-propoxy}-phenyl)-2-ethyl-2H-tetrazole (compound 1.4).

Workup

  1. additionThe reaction mixture is poured onto water
  2. extractionextracted with ethyl acetate
  3. customConcentration of the organic phase and purification over silica gel

Sources & evidence

ORD record
ord-8a5c4f1ac9bc46d78118e4ad01efcb28
Source dataset
uspto-grants-2009_10
Patent number
US07608631B2

Reaction notes

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