4-Nitrobenzaldehyde → HCID 178477495, compound

HRID 1822499Notes

Reaction equation

HRID 1822499 reaction equation
O=Cc1ccc([N+](=O)[O-])cc1.CCSC(=O)C(OCc1ccccc1)C(=O)O>C1CCNC1.CN(C)c1ccncc1.C1CCOC1>CCSC(=O)/C(=C/c1ccc([N+](=O)[O-])cc1)OCc1ccccc1

Participants

6

Reactant 2

HCID 5414-NitrobenzaldehydeHCID 178477513HCID 178477513, compound

Product 1

HCID 178477495HCID 178477495, compoundYield 42%

Reagents, catalysts & solvents 3

HCID 142844-(Dimethylamino)pyridineReagentHCID 31268PyrrolidineCatalystHCID 8028TetrahydrofuranSolvent

Conditions

Temperature
50 °C

Workup

  1. temperatureThe product mixture was cooled to 25 °C.
  2. filtrationFiltered through a pad of celite · Keep Organic
  3. wash"The celite was washed with ethyl acetate (3 x 1 mL)."
  4. concentrationThe filtrate was concentrated under reduced pressure
  5. additionA 0.07 M stock solution of the internal standard ethylene carbonate (0.70 mL in CDCl3) was added.

Sources & evidence

ORD record
ord-3b029fa2e4644d8e9a1fbd0e2c65c49e
Source dataset
Bayesian optimization of 5 decarboxylative olefination reactions

Reaction notes

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