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HRID1829703

反应详情

EQUATION

反应方程式

HRID 1829703 的结构方程式

REACTANTS

反应物

2
结构：O=C([O-])[O-].[K+].[K+]
HCID11430

Potassium Carbonate

CK2O3

结构：CCOC(=O)Cc1cccc(NC(=O)c2c(-c3c(F)cccc3Cl)noc2C)n1
HCID69632684

未命名化合物

PRODUCTS

生成物

1
结构：CCOC(=O)Cc1cccc(-n2c(=O)c3c(C)onc3c3c(Cl)cccc32)n1
HCID9930712

未命名化合物

收率 79%

AUXILIARIES

试剂、催化剂与溶剂

2
结构：CN(C)C=O
溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

结构：CCOC(C)=O
溶剂HCID8857

Ethyl acetate

C4H8O2

PROCEDURE

实验过程

Add powdered K2CO3 (0.661 g, 4.8 mmol) to a solution of (6-{[3-(2-Chloro-6-fluorophenyl)-5-methyl-isoxazole-4-carbonyl]-amino}-pyridin-2-yl)-acetic acid ethyl ester (0.5 g, 1.2 mmol) in DMF (20 ml) under N2 and stirred overnight. Dilute with EtOAc, wash (H2O then brine), dry (MgSO4), filter, and concentrate. Column chromatography (silica gel, hexanes/EtOAc gradient) gives the title compound (0.376 g, 79%). Mass Spectrum (FIA) (m/z) 398.1 [M+1]

WORKUP

后处理

  1. washwash (H2O
  2. dry with materialbrine), dry (MgSO4)
  3. filtrationfilter
  4. concentrationconcentrate