Hydrochloric Acid → HCID 21388814, compound

HRID 1833725Notes

Reaction equation

HRID 1833725 reaction equation
Cl.C(OC(=O)C(=COCC)C(OCC)=O)C.CC[O-].[Na+].C(O[C:24]([C:26]1[C:27](O)=[N:28][C:29]([C:32]2[CH:37]=[CH:36][C:35]([CH2:38][CH2:39][CH2:40][CH3:41])=[CH:34][CH:33]=2)=[N:30][CH:31]=1)=O)C.P(Cl)(Cl)(Cl)=O.C(OC(C1C(Cl)=[N:55]C(C2C=CC(CCCC)=CC=2)=NC=1)=O)C>C(O)C>[C:24]([C:26]1[CH:27]=[N:28][C:29]([C:32]2[CH:37]=[CH:36][C:35]([CH2:38][CH2:39][CH2:40][CH3:41])=[CH:34][CH:33]=2)=[N:30][CH:31]=1)#[N:55]

Participants

8

Reactant 6

HCID 313Hydrochloric AcidHCID 6871Diethyl (ethoxymethylene)malonateHCID 24813Phosphorus oxychlorideHCID 2723922Sodium ethoxideHCID 54377863HCID 54377863, compoundHCID 178440774HCID 178440774, compound

Product 1

HCID 21388814HCID 21388814, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

The starting material can be obtained according to the procedure of A. R. Todd and F. Bergel, J. Chem. Soc. 1937, 366 from p-n-butylbenzamindine hydrochloride and ethoxymethylenemalonic acid diethyl ester with sodium ethylate in ethanol and subsequent treatment of the obtained 2-(p-n-butylphenyl)-4-hydroxy-5-pyrimidinecarboxylic acid ethyl ester (melting point 198.0°-198.8° C) with phosphorus oxychloride. The melting point of 2-(p-n-butylphenyl)-4-chloro-5-pyrimidinecarboxylic acid ethyl ester is 64.9°-65.3° C.

Workup

  1. customThe starting material can be obtained
  2. customis 64.9°-65.3° C.

Sources & evidence

ORD record
ord-265c81d4db6f421a9411b516a15464dc
Source dataset
uspto-grants-1978_01
Patent number
US04066570

Reaction notes

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