Ammonium → tert-butyl 5-[1-hydroxy-4-methyl-3-(phenylmethoxymethyl)pentyl]-2-[4-methoxy-3-(3-methoxypropoxy)phenyl]-3-propan-2-ylpyrrolidine-1-carboxylate

HRID 183659Notes

Reaction equation

HRID 183659 reaction equation
[Br:32][CH2:33][CH:34]([CH2:35][O:36][CH2:37][c:38]1[cH:39][cH:40][cH:41][cH:42][cH:43]1)[CH:44]([CH3:45])[CH3:46].[Br:48][CH2:49][CH2:50][Br:51].[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH:9]([c:18]2[cH:19][c:20]([O:26][CH2:27][CH2:28][CH2:29][O:30][CH3:31])[c:21]([O:24][CH3:25])[cH:22][cH:23]2)[CH:10]([CH:15]([CH3:16])[CH3:17])[CH2:11][CH:12]1[CH:13]=[O:14].[C:64]([O:65][CH3:66])([CH3:67])([CH3:68])[CH3:69].[CH2:59]([O:60][CH2:61][CH3:62])[CH3:63].[Cl-:52].[Mg:47].[NH4+:53].[O:54]1[CH2:55][CH2:56][CH2:57][CH2:58]1>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH:9]([c:18]2[cH:19][c:20]([O:26][CH2:27][CH2:28][CH2:29][O:30][CH3:31])[c:21]([O:24][CH3:25])[cH:22][cH:23]2)[CH:10]([CH:15]([CH3:16])[CH3:17])[CH2:11][CH:12]1[CH:13]([OH:14])[CH2:33][CH:34]([CH2:35][O:36][CH2:37][c:38]1[cH:39][cH:40][cH:41][cH:42][cH:43]1)[CH:44]([CH3:45])[CH3:46]

Participants

10

Reactant 9

HCID 223AmmoniumHCID 312ChlorideHCID 3283Diethyl EtherHCID 78391,2-DibromoethaneHCID 8028TetrahydrofuranHCID 15413tert-Butyl methyl etherHCID 5462224MagnesiumHCID 44181768((2-(Bromomethyl)-3-methylbutoxy)methyl)benzeneHCID 73173825Tert-butyl 5-formyl-2-[4-methoxy-3-(3-methoxypropoxy)phenyl]-3-propan-2-ylpyrrolidine-1-carboxylate

Product 1

HCID 178495322tert-butyl 5-[1-hydroxy-4-methyl-3-(phenylmethoxymethyl)pentyl]-2-[4-methoxy-3-(3-methoxypropoxy)phenyl]-3-propan-2-ylpyrrolidine-1-carboxylate

Sources & evidence

ORD record
ord-ec2b82a6844c488898cdcb021ec43954
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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