Chloride → tert-butyl 4-(1,3-oxazol-2-yl)-3,6-dihydro-2H-pyridine-1-carboxylate

HRID 183717Notes

Reaction equation

HRID 183717 reaction equation
[C:11]([CH3:12])([CH3:13])([CH3:14])[O:15][C:16](=[O:17])[N:18]1[CH2:19][CH2:20][C:21]([O:24][S:25]([C:26]([F:27])([F:28])[F:29])(=[O:30])=[O:31])=[CH:22][CH2:23]1.[CH2:6]([Li:7])[CH2:8][CH2:9][CH3:10].[CH3:46][CH2:47][O:48][C:49](=[O:50])[CH3:51].[Cl-:52].[Cl-:54].[O-:32][S:33]([C:34]([F:35])([F:36])[F:37])(=[O:38])=[O:39].[O:40]1[CH2:41][CH2:42][CH2:43][CH2:44]1.[Pd:45].[Zn+2:53].[o:1]1[cH:2][n:3][cH:4][cH:5]1>>[o:1]1[c:2]([C:21]2=[CH:20][CH2:19][N:18]([C:16]([O:15][C:11]([CH3:12])([CH3:13])[CH3:14])=[O:17])[CH2:23][CH2:22]2)[n:3][cH:4][cH:5]1

Participants

10

Reactant 9

HCID 312Chloride2×HCID 8028TetrahydrofuranHCID 8857Ethyl AcetateHCID 9255OxazoleHCID 23938PalladiumHCID 32051Zinc(2+)HCID 2758875TrifluoromethanesulfonateHCID 10991161Tert-butyl 4-(trifluoromethanesulfonyloxy)-1,2,3,6-tetrahydropyridine-1-carboxylateHCID 178418339Butyllithium

Product 1

HCID 68876762tert-butyl 4-(1,3-oxazol-2-yl)-3,6-dihydro-2H-pyridine-1-carboxylate

Sources & evidence

ORD record
ord-12ae8173af5f4f0c9b811ceae7ffb142
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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