Sodium Thiosulfate → Benzoic acid, chloroacetylmethyl ester

To the mixture consisting of 30 mmol (6.44 g) of 1-benzoyloxy-3-chloro-2-propanol, 1.5 mmol (234 mg) of 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO), 33 mmol (3.4 g) of sodium bromide, 90 mmol (7.50 g) of sodium hydrogencarbonate, 75 ml of ethyl acetate and 35 ml of water was added dropwise 45 mmol (30 g) of sodium hypochlorite aqueous solution (1.5 mmol/g) under cooling with ice. Temperature of the reaction system was about 4° C. and pH was about 8.5. After the dropping was completed, stirring was further continued for 30 minute. Thereto was added 20 ml of a 5% sodium thiosulfate aqueous solution and the organic layer was separated. The organic layer was dried over anhydrous sodium sulfate, filtered off and concentrated under reduced pressure to obtain a crude product. It was purified with silica gel column to obtain 5.56 g of 1-benzoyloxy-3-chloro-2-propanon. The yield was 87%.

1. temperatureunder cooling with ice
2. customwas about 4° C.
3. customthe organic layer was separated
4. dry with materialThe organic layer was dried over anhydrous sodium sulfate
5. filtrationfiltered off
6. concentrationconcentrated under reduced pressure
7. customto obtain a crude product
8. customIt was purified with silica gel column

ORD record

ord-4d0cdab0f59046bbaa3c582d57a9f2a1

Source dataset

uspto-grants-2004_01

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US06682916B2