2-Bromopropane → HCID 178505971, compound

Air inside a reaction vessel of the same kind as the one used in Example 13 is displaced by a nitrogen gas in a satisfactory manner. Then, 2.025 g (0.083 mole) of magnesium, 13.198 g (0.079 mole) of pentafluorobenzene, and 20 ml of tetrahydrofuran (THF) serving as the solvent (e) (ether solvent (e)) are charged to the reaction vessel. Also, 10.782 g (0.083 mole) of isopropyl bromide is charged to the dropping funnel. Next, isopropyl bromide is dropped to the above contents with stirring under a nitrogen gas flow. After the completion of the dropping, the resulting reaction solution is subject to reaction for 2 hours at 57.0° C. with stirring. Consequently, pentafluorophenyl magnesium bromide is obtained in the form of a THF solution. A reaction yield of pentafluorophenyl magnesium bromide found in the same manner as Example 13 is 82.9 percent by mole.

1. customAir inside a reaction vessel of the same kind as the one used in Example 13
2. additionare charged to the reaction vessel
3. customAfter the completion of the dropping, the resulting reaction solution
4. customis subject to reaction for 2 hours at 57.0° C.
5. stirringwith stirring

ORD record

ord-7fd87c67d3db41438fbb3652b0bf4aa8

Source dataset

uspto-grants-2004_01

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US06683218B1