反应详情

Phosgene (0.5 ml, 20% solution in toluene) was added in one portion to a stirred solution of piperidine (0.1 g, 0.7 mmol) in THF (2 ml) and the resulting mixture was stirred at room temperature under a nitrogen atmosphere for 3 hours. After this time the reaction mixture was concentrated under vacuum and the resulting residue was diluted with DMF (2 ml) and added drop wise to a stirred solution of N-[4-(Piperazine-1-sulfonyl)-phenyl]-acrylamide (0.16 g, 0.54 mmol) and diisopropylethylamine (0.19 ml, 1.1 mmol) in DMF (4 ml). The resulting mixture was stirred at room temperature under a nitrogen atmosphere for 18 hours. After this time the reaction mixture was concentrated under vacuum and the residue was purified by Prep HPLC to give the title compound (0.032 g, 14% yield) as a white powder.

1. concentrationAfter this time the reaction mixture was concentrated under vacuum
2. additionthe resulting residue was diluted with DMF (2 ml)
3. stirringThe resulting mixture was stirred at room temperature under a nitrogen atmosphere for 18 hours
4. concentrationAfter this time the reaction mixture was concentrated under vacuum
5. customthe residue was purified by Prep HPLC