Hydrochloric Acid → HCID 66634452, compound

HRID 1842057Notes

Reaction equation

HRID 1842057 reaction equation
[F:1][C:2]1[CH:30]=[CH:29][CH:28]=[CH:27][C:3]=1[CH2:4][N:5]1[CH2:10][CH2:9][S:8][CH:7]([C:11]([NH:13][C:14]2[CH:15]=[C:16]3[C:20](=[CH:21][CH:22]=2)[NH:19][N:18]=[C:17]3[C:23]([O:25]C)=[O:24])=[O:12])[CH2:6]1.[Li+].[OH-].Cl>C1COCC1>[F:1][C:2]1[CH:30]=[CH:29][CH:28]=[CH:27][C:3]=1[CH2:4][N:5]1[CH2:10][CH2:9][S:8][CH:7]([C:11]([NH:13][C:14]2[CH:15]=[C:16]3[C:20](=[CH:21][CH:22]=2)[NH:19][N:18]=[C:17]3[C:23]([OH:25])=[O:24])=[O:12])[CH2:6]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 3939Lithium HydroxideHCID 66614832HCID 66614832, compound

Product 1

HCID 66634452HCID 66634452, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To a solution of methyl 5-(4-(2-fluorobenzyl)thiomorpholine-2-carboxamido)-1H-indazole-3-carboxylate (250 mg, 0.58 mmol) in THF (4 mL), was added LiOH (1.2 mL, 1M, 1.2 mmol). The resulted solution was stirred at RT for overnight. 1 N HCl was added to the reaction mixture until pH reached around 4. The solvent was removed and the residual was used directly for the next step. LC-MS: 415.1 [M+H]

Workup

  1. customThe solvent was removed

Sources & evidence

ORD record
ord-a2ff87f7c384472eb83843a7679b1b9b
Source dataset
uspto-grants-2015_02
Patent number
US08946216B2

Reaction notes

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