Water → HCID 86663892, compound

HRID 1846420Notes

Reaction equation

HRID 1846420 reaction equation
[H-].[Na+].[OH:3][C:4]1[CH:14]=[C:13]([CH3:15])[C:7]2[N:8]([CH3:12])[C:9](=[O:11])[O:10][C:6]=2[CH:5]=1.[Cl:16][C:17]1[CH:22]=[C:21](Cl)[N:20]=[CH:19][N:18]=1.O>CN(C=O)C.CCOC(C)=O>[Cl:16][C:17]1[N:18]=[CH:19][N:20]=[C:21]([O:3][C:4]2[CH:14]=[C:13]([CH3:15])[C:7]3[N:8]([CH3:12])[C:9](=[O:11])[O:10][C:6]=3[CH:5]=2)[CH:22]=1

Participants

7

Reactant 4

HCID 962WaterHCID 24758Sodium hydrideHCID 709434,6-DichloropyrimidineHCID 66978330HCID 66978330, compound

Product 1

HCID 86663892HCID 86663892, compound

Reagents, catalysts & solvents 2

HCID 6228DimethylformamideSolventHCID 8857Ethyl AcetateSolvent

Procedure

30 mg (0.70 mmol) sodium hydride (55%, suspension in mineral oil) were added to 0.12 g (0.70 mmol) 6-hydroxy-3,4-dimethyl-3H-benzoxazol-2-one in 5.0 ml DMF and the mixture was stirred for 10 min at RT. Then 0.10 g (0.70 mmol) 4,6-dichloropyrimidine was added and the mixture was stirred for 1 h at RT. Then water and EtOAc were added, the organic phase was separated off, dried on sodium sulphate, filtered and evaporated down.

Workup

  1. stirringthe mixture was stirred for 1 h at RT
  2. customthe organic phase was separated off
  3. customdried on sodium sulphate
  4. filtrationfiltered
  5. customevaporated down

Sources & evidence

ORD record
ord-608b99995bec4927aee5f5c4ef542e05
Source dataset
uspto-grants-2015_02
Patent number
US08952014B2

Reaction notes

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