Triethylamine → HCID 26470965, compound

HRID 1848809Notes

Reaction equation

HRID 1848809 reaction equation
F[C:2]1[CH:7]=[CH:6][C:5]([S:8]([NH2:11])(=[O:10])=[O:9])=[CH:4][C:3]=1[N+:12]([O-:14])=[O:13].[N:15]1([CH2:21][CH2:22][CH2:23][NH2:24])[CH2:20][CH2:19][O:18][CH2:17][CH2:16]1.C(N(CC)CC)C>C1COCC1.C(OCC)(=O)C>[O:18]1[CH2:19][CH2:20][N:15]([CH2:21][CH2:22][CH2:23][NH:24][C:2]2[CH:7]=[CH:6][C:5]([S:8]([NH2:11])(=[O:10])=[O:9])=[CH:4][C:3]=2[N+:12]([O-:14])=[O:13])[CH2:16][CH2:17]1

Participants

6

Reactant 3

HCID 8471TriethylamineHCID 61055N-(3-Aminopropyl)morpholineHCID 167824874-Fluoro-3-nitrobenzenesulfonamide

Product 1

HCID 26470965HCID 26470965, compound

Reagents, catalysts & solvents 2

HCID 8028TetrahydrofuranSolventHCID 8857Ethyl AcetateSolvent

Procedure

4-Fluoro-3-nitrobenzenesulfonamide (550 mg), 3-(N-morpholinyl)-1-propylamine (1.00 g), and triethylamine (1 g) were stirred in THF (30 mL) for 24 hours. The mixture was diluted with ethyl acetate, washed with NaH2PO4 solution and brine, and dried (Na2SO4), filtered and concentrated. The product was triturated from ethyl acetate.

Workup

  1. washwashed with NaH2PO4 solution and brine
  2. dry with materialdried (Na2SO4)
  3. filtrationfiltered
  4. concentrationconcentrated
  5. customThe product was triturated from ethyl acetate

Sources & evidence

ORD record
ord-e4da83e34cf24ee19b01dfe65fe2f577
Source dataset
uspto-grants-2015_02
Patent number
US08952157B2

Reaction notes

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