Acetic Acid → Tert-butyl azetidin-3-ylcarbamate acetate

HRID 1856653Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1856653
[C:1]([O:5][C:6](=[O:25])[NH:7][CH:8]1[CH2:11][N:10](C(C2C=CC=CC=2)C2C=CC=CC=2)[CH2:9]1)([CH3:4])([CH3:3])[CH3:2].O.[C:27]([OH:30])(=[O:29])[CH3:28]>C(O)C.[Pd]>[C:27]([OH:30])(=[O:29])[CH3:28].[C:1]([O:5][C:6](=[O:25])[NH:7][CH:8]1[CH2:11][NH:10][CH2:9]1)([CH3:4])([CH3:2])[CH3:3]

Komponenten

6

Edukt 3

HCID 176Acetic AcidHCID 962WaterHCID 13772848tert-Butyl (1-benzhydrylazetidin-3-yl)carbamate

Produkt 1

HCID 21904480Tert-butyl azetidin-3-ylcarbamate acetate

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

A suspension of 14 (4.6 g, 13.6 mmol) and 10% Pd/C (2.0 g) in 200 ml of 10:2:1 ethanol:water:acetic acid was hydrogenated at 50 psi for 24 hours. The suspension was subsequently filtered through celite and the solvents removed in vacuo to give the title compound.

Aufarbeitung

  1. filtrationThe suspension was subsequently filtered through celite
  2. customthe solvents removed in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-a46d8f780040490b894d19a4de89a2cf
Quelldatensatz
uspto-grants-2000_11
Patentnummer
US06143750

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