Hydrochloric Acid → HCID 66919021, compound

HRID 1861046Notes

Reaction equation

HRID 1861046 reaction equation
[CH3:1][C:2](=[CH:30][C:31]1[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=1)[C:3]([N:5]1[C@@H:9]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[C@H:8]([C:16]([O:18]C)=[O:17])[O:7][CH:6]1[C:20]1[CH:25]=[CH:24][C:23]([O:26][CH3:27])=[C:22]([O:28][CH3:29])[CH:21]=1)=[O:4].[Li+].[OH-].Cl>C1COCC1>[CH3:1][C:2](=[CH:30][C:31]1[CH:32]=[CH:33][CH:34]=[CH:35][CH:36]=1)[C:3]([N:5]1[C@@H:9]([C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=2)[C@H:8]([C:16]([OH:18])=[O:17])[O:7][CH:6]1[C:20]1[CH:25]=[CH:24][C:23]([O:26][CH3:27])=[C:22]([O:28][CH3:29])[CH:21]=1)=[O:4]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 3939Lithium HydroxideHCID 66919000HCID 66919000, compound

Product 1

HCID 66919021HCID 66919021, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Compound 3 (25 g) in 125 ml of THF was added with 63 ml of 1N LiOH at room temperature. After 30 minutes, the mixture was adjusted to a pH of 2 by adding 1N HCl. After separation of the aqueous part, the organic part was washed with brine and dried over MgSO4. Removing the solvent under reduced pressure gave quantitatively Compound 4.

Workup

  1. customAfter separation of the aqueous part
  2. washthe organic part was washed with brine
  3. dry with materialdried over MgSO4
  4. customRemoving the solvent under reduced pressure

Sources & evidence

ORD record
ord-7b7a12ad73a347afbcf019679f655749
Source dataset
uspto-grants-2003_03
Patent number
US06531611B2

Reaction notes

Loading…