Dimethylformamide → HCID 18695404, compound

HRID 1870203Notes

Reaction equation

HRID 1870203 reaction equation
F[C:2]1[CH:7]=[C:6]([F:8])[C:5]([F:9])=[CH:4][C:3]=1[N+:10]([O-:12])=[O:11].C(N(CC)CC)C.CN(C=O)C.Cl.[CH2:26]([O:28][C:29](=[O:32])[CH2:30][NH2:31])[CH3:27]>C1COCC1>[CH2:26]([O:28][C:29](=[O:32])[CH2:30][NH:31][C:2]1[CH:7]=[C:6]([F:8])[C:5]([F:9])=[CH:4][C:3]=1[N+:10]([O-:12])=[O:11])[CH3:27]

Participants

6

Reactant 4

HCID 6228DimethylformamideHCID 8471TriethylamineHCID 750121,2,4-Trifluoro-5-nitrobenzeneHCID 2723640Glycine ethyl ester, hydrochloride

Product 1

HCID 18695404HCID 18695404, compoundYield 20.1%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

By using 2.00 g of 2,4,5-trifluoronitrobenzene, 3.43 g of triethylamine, 25 ml of DMF, 25 ml of THF and 1.58 g of glycine ethyl ester hydrochloride, 0.59 g (20%) of N-(4,5-difluoro-2-nitrophenyl)glycine ethyl ester was obtained.

Sources & evidence

ORD record
ord-3513d2ad17244231b2f8958b66d86ec2
Source dataset
uspto-grants-2000_08
Patent number
US06096743

Reaction notes

Loading…