Ethyl 3-(methylamino)propanoate → HCID 59529585, compound

HRID 1877153Notes

Reaction equation

HRID 1877153 reaction equation
[CH3:1][N:2]1[CH:6]=[C:5]([C:7]2[O:11][C:10]([CH3:12])=[C:9]([CH:13]([NH:18][C:19]3[CH:27]=[CH:26][C:22](C(O)=O)=[CH:21][CH:20]=3)[CH2:14][CH:15]([CH3:17])[CH3:16])[CH:8]=2)[CH:4]=[N:3]1.[CH3:28][NH:29][CH2:30][CH2:31][C:32]([O:34]CC)=[O:33].Cl.C(N=C=NCCCN(C)C)C.O.[OH:50][C:51]1C2N=NNC=2C=CC=1>CN(C)C=O.C(OCC)(=O)C.C(N(CC)CC)C>[CH3:17][CH:15]([CH3:16])[CH2:14][CH:13]([NH:18][C:19]1[CH:27]=[CH:26][C:22]([C:51]([N:29]([CH3:28])[CH2:30][CH2:31][C:32]([OH:34])=[O:33])=[O:50])=[CH:21][CH:20]=1)[C:9]1[CH:8]=[C:7]([C:5]2[CH:4]=[N:3][N:2]([CH3:1])[CH:6]=2)[O:11][C:10]=1[CH3:12]

Participants

8

Reactant 4

HCID 541480Ethyl 3-(methylamino)propanoateHCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideHCID 68512261HCID 68512261, compoundHCID 178526939HCID 178526939, compound

Product 1

HCID 59529585HCID 59529585, compoundYield 90%

Reagents, catalysts & solvents 3

HCID 6228DimethylformamideSolventHCID 8471TriethylamineSolventHCID 8857Ethyl AcetateSolvent

Procedure

A solution of 4-({1-[5-(1-methyl-1H-pyrazol-4-yl)-2-methylfuran-3-yl]-3-methylbutyl}amino)benzoic acid (184 mg), ethyl 3-(methylamino)propanoate (79 mg), 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (115 mg), hydroxybenzotriazole monohydrate (92 mg) and triethylamine (84 μL) in N,N-dimethylformamide (10 mL) was stirred at room temperature for 4 hr. Ethyl acetate was added, the mixture was washed with saturated aqueous sodium hydrogen carbonate solution and water, and the organic layer was dried over magnesium sulfate. The solvent was evaporated under reduced pressure, and the organic layer was dried over magnesium sulfate. The solvent was evaporated under reduced pressure. To the residue were added ethanol (2 mL), tetrahydrofuran (2 mL) and 1N lithium hydroxide (1.0 mL), and the mixture was stirred at room temperature for 1 hr. The solvent was evaporated under reduced pressure, and water (10 mL) was added. The mixture was neutralized with 1N hydrochloric acid under ice-cooling, and stirred for 1 hr. The resulting precipitate was collected by filtration and dried to give the title compound (204 mg, 90%).

Workup

  1. washthe mixture was washed with saturated aqueous sodium hydrogen carbonate solution and water
  2. dry with materialthe organic layer was dried over magnesium sulfate
  3. customThe solvent was evaporated under reduced pressure
  4. dry with materialthe organic layer was dried over magnesium sulfate
  5. customThe solvent was evaporated under reduced pressure
  6. additionTo the residue were added ethanol (2 mL), tetrahydrofuran (2 mL) and 1N lithium hydroxide (1.0 mL)
  7. customThe solvent was evaporated under reduced pressure, and water (10 mL)
  8. additionwas added
  9. temperaturecooling
  10. stirringstirred for 1 hr
  11. filtrationThe resulting precipitate was collected by filtration
  12. customdried

Sources & evidence

ORD record
ord-14864f5f379b4854baaa95a9b068380d
Source dataset
uspto-grants-2012_11
Patent number
US08309580B2

Reaction notes

Loading…