Tetrahydrofuran → 4-(Cyclopropylethynyl)-3-fluoroaniline

HRID 188225Notes

Reaction equation

HRID 188225 reaction equation
[CH2:22]1[O:23][CH2:24][CH2:25][CH2:26]1.[CH3:10][CH2:11][N:12]([CH2:13][CH3:14])[CH2:15][CH3:16].[CH:17]1([C:20]#[CH:21])[CH2:18][CH2:19]1.[Cu:27][I:28].[I:1][c:2]1[c:3]([F:9])[cH:4][c:5]([NH2:6])[cH:7][cH:8]1>>[c:2]1([C:21]#[C:20][CH:17]2[CH2:18][CH2:19]2)[c:3]([F:9])[cH:4][c:5]([NH2:6])[cH:7][cH:8]1

Participants

6

Reactant 5

HCID 8028TetrahydrofuranHCID 8471TriethylamineHCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)HCID 138823CyclopropylacetyleneHCID 154755463-Fluoro-4-iodoaniline

Product 1

HCID 596373074-(Cyclopropylethynyl)-3-fluoroaniline

Sources & evidence

ORD record
ord-00144fd0006e4241a07c1a015ae1db63
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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