Iodine → HCID 13487918, compound

HRID 1883213Notes

Reaction equation

[S:1]1[CH:5]=[CH:4][C:3]([C:6]([OH:8])=O)=[CH:2]1.C([N-]C(C)C)(C)C.[Li+].[I:17]I.COS([O:24][CH3:25])(=O)=O.C([O-])([O-])=O.[K+].[K+]>>[I:17][C:4]1[C:3]([C:6]([O:24][CH3:25])=[O:8])=[CH:2][S:1][CH:5]=1

Participants

Reactant 5

HCID 807Iodine

HCID 6497Dimethyl Sulfate

HCID 6918Thiophene-3-carboxylic acid

HCID 11430Potassium Carbonate

HCID 2724682Lithium diisopropylamide

Product 1

HCID 13487918HCID 13487918, compound

Procedure

Thiophene-3-caboxylic acid was treated with lithium diisopropylamide and iodine, and the resultant was reacted with (CH3)2SO4 in the presence of K2CO3 to give methyl 4-iodothiophene-3-carboxylate.

Sources & evidence

ORD record: ord-f954eaa72c4346728572205da18892ea
Source dataset: uspto-grants-2004_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06759429B2

Reaction notes

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