反应详情

温度

5 °C

4-(4-Hydroxy-cyclohexylamino)-2-trifluoromethyl-benzonitrile (4.30 mmol) is dissolved in dry tetrahydrofuran (10 mL) and sodium hydride (60% suspension in oil, 13.0 mmol) is added. The resulting mixture is stirred for 15 minutes and is cooled down to 5° C. prior to the addition of acetic acid tert-butyl ester (4.30 mmol). After 1.5 hours reaction time, water (7 mL) is slowly added under vigorous stirring and the mixture is then diluted with ethyl acetate (25 mL). The organic phase is collected and is concentrated under reduced pressure. The residue obtained is then treated with a 1 to 1 mixture of dichloromethane and trifluoroacetic acid (10 mL). After 2 hours, the reaction mixture is concentrated under reduced pressure. The residue obtained is taken up in dichloromethane (20 mL) and the organic phase is extracted with aqueous 3N sodium hydroxide solution (3×7 mL) and washed with water (2×5 mL). The pH of all combined aqueous phases is then brought to 5-6 by the addition of aqueous 5N hydrochloric acid. The acidic aqueous phase is extracted with dichloromethane (4×15 mL) and the combined organic layers are dried over magnesium sulphate, filtered and concentrated under reduced pressure to afford the desired acid (39% yield).

1. additionis slowly added
2. stirringunder vigorous stirring
3. customThe organic phase is collected
4. concentrationis concentrated under reduced pressure
5. customThe residue obtained
6. waitAfter 2 hours
7. concentrationthe reaction mixture is concentrated under reduced pressure
8. customThe residue obtained
9. extractionthe organic phase is extracted with aqueous 3N sodium hydroxide solution (3×7 mL)
10. washwashed with water (2×5 mL)
11. additionThe pH of all combined aqueous phases is then brought to 5-6 by the addition of aqueous 5N hydrochloric acid
12. extractionThe acidic aqueous phase is extracted with dichloromethane (4×15 mL)
13. dry with materialthe combined organic layers are dried over magnesium sulphate
14. filtrationfiltered
15. concentrationconcentrated under reduced pressure