反应详情

温度

5 °C

A solution of 4-dimethylamino-3-phenyl-3-buten-2-one (30.3 g) and diethyl oxalate (43.5 ml) in ethanol (75 ml) was added to a stirred solution of sodium ethoxide prepared by dissolving sodium (5.5 g) in ethanol (150 ml). The stirred mixture was heated under reflux for 1 hour, cooled to 20°-25° C. and acidified by addition of 5 N hydrochloric acid (150 ml). The mixture was stirred for a further hour, then cooled to 5° C., and diluted with water (300 ml). The solid title product was recrystallised from ethanol-water (mp 110°-112° C.).

1. customprepared
2. temperatureThe stirred mixture was heated
3. temperatureunder reflux for 1 hour
4. temperaturecooled to 20°-25° C.
5. customThe solid title product was recrystallised from ethanol-water (mp 110°-112° C.)