Iodoethane → HCID 20210647, compound

HRID 1906851Notes

Reaction equation

HRID 1906851 reaction equation
[C:1]([C:9]1[CH:10]=[N:11][N:12]2[C:17]([C:18]3[CH:19]=[C:20]([NH:24][CH:25]=[O:26])[CH:21]=[CH:22][CH:23]=3)=[CH:16][CH:15]=[N:14][C:13]=12)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[H-].[Na+].[CH2:29](I)[CH3:30]>CN(C)C=O>[C:1]([C:9]1[CH:10]=[N:11][N:12]2[C:17]([C:18]3[CH:19]=[C:20]([N:24]([CH2:29][CH3:30])[CH:25]=[O:26])[CH:21]=[CH:22][CH:23]=3)=[CH:16][CH:15]=[N:14][C:13]=12)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 6340IodoethaneHCID 24758Sodium hydrideHCID 13824243HCID 13824243, compound

Product 1

HCID 20210647HCID 20210647, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

As described for Example 59, 0.01 mole of N-[3-(3-benzoylpyrazolo[1,5-a]pyrimidin-7-yl]phenyl]formamide in 30 ml of dimethylformamide is reacted with 0.384 g of 60% sodium hydride in oil. To the mixture is added 0.85 ml of ethyl iodide and the mixture stirred overnight. Work up as for Example 59 gives the desired product.

Sources & evidence

ORD record
ord-3a74657925dc4d70b7185fe0c0da5c86
Source dataset
uspto-grants-1987_03
Patent number
US04654347

Reaction notes

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