反应详情

To a solution of 4-nitropyrrazole (2.0 g) in DMF was added NaH (60% dispersion in oil) under ice cooling. After stirring at the same temperature for 10 minutes, 2-bromoethyl methyl ether (2.00 ml) and NaI (2.92 g) was added. The mixture was then stirred at room temperature for 3 hours, quenched by phosphate buffer solution (pH=7) and extracted with EtOAc. The extract was washed with H2O and brine, dried over MgSO4, and evaporated in vacuo. The residue was purified by column chromatography on silica gel to give 1-(2-methoxyethyl)-4-nitro-1H-pyrazole (2.15 g).

1. stirringThe mixture was then stirred at room temperature for 3 hours
2. customquenched by phosphate buffer solution (pH=7)
3. extractionextracted with EtOAc
4. washThe extract was washed with H2O and brine
5. dry with materialdried over MgSO4
6. customevaporated in vacuo
7. customThe residue was purified by column chromatography on silica gel