反应详情

A solution of 300 mg (1.10 mmol) (1S,4S)-2-methyl-2,5-diazabicylo[2.2.1]heptane dihydrobromide, 0.75 mL (4.40 mmol) ethyldiisopropylamine and 270 mg (1.11 mmol) 2,5-dibromopyridine in 1.5 mL n-butanol are stirred for 18 h at 115° C. The solvent is eliminated i.vac., the residue is combined with 10 mL EtOAc and acidified with 1 M HCl. The aqueous phase is twice made alkaline with 2 M K2CO3 solution and extracted with 30 mL EtOAc. The combined organic extracts are dried over Na2SO4 and the solvent is eliminated i.vac.

1. extractionextracted with 30 mL EtOAc
2. dry with materialThe combined organic extracts are dried over Na2SO4