反应详情

A solution of 2 g (8.11 mmol) 5-bromo-2-chloromethyl-benzoxazole in 30 mL DMF is combined with 2.24 g (16.22 mmol) K2CO3 and 0.9 mL (10.78 mmol) pyrrolidine and stirred for 24 hours at RT. The reaction mixture is diluted with water and extracted with EtOAc. The organic phase is dried over Na2SO4, the desiccant is filtered off and the filtrate is evaporated down.

1. extractionextracted with EtOAc
2. dry with materialThe organic phase is dried over Na2SO4
3. filtrationthe desiccant is filtered off
4. customthe filtrate is evaporated down