Potassium Carbonate → HCID 67365573, compound

HRID 1916761Notes

Reaction equation

HRID 1916761 reaction equation
[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[O:9][C:8]([CH2:10]Cl)=[N:7][C:6]=2[CH:12]=1.C([O-])([O-])=O.[K+].[K+].[NH:19]1[CH2:23][CH2:22][CH2:21][CH2:20]1>CN(C=O)C.O>[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[O:9][C:8]([CH2:10][N:19]3[CH2:23][CH2:22][CH2:21][CH2:20]3)=[N:7][C:6]=2[CH:12]=1

Participants

6

Reactant 3

HCID 11430Potassium CarbonateHCID 31268PyrrolidineHCID 142042085-Bromo-2-(chloromethyl)-1,3-benzoxazole

Product 1

HCID 67365573HCID 67365573, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 6228DimethylformamideSolvent

Procedure

A solution of 2 g (8.11 mmol) 5-bromo-2-chloromethyl-benzoxazole in 30 mL DMF is combined with 2.24 g (16.22 mmol) K2CO3 and 0.9 mL (10.78 mmol) pyrrolidine and stirred for 24 hours at RT. The reaction mixture is diluted with water and extracted with EtOAc. The organic phase is dried over Na2SO4, the desiccant is filtered off and the filtrate is evaporated down.

Workup

  1. extractionextracted with EtOAc
  2. dry with materialThe organic phase is dried over Na2SO4
  3. filtrationthe desiccant is filtered off
  4. customthe filtrate is evaporated down

Sources & evidence

ORD record
ord-60132da22cba45ec88c52177cc03b648
Source dataset
uspto-grants-2013_12
Patent number
US08618132B2

Reaction notes

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