2-Bromopropane → HCID 57652506, compound

HRID 1930216Notes

Reaction equation

HRID 1930216 reaction equation
[F:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([CH3:13])=[CH:7][NH:8][C:9]2=[O:12])=[CH:4][C:3]=1[O:14][CH:15]1[CH2:20][CH2:19][NH:18][CH2:17][CH2:16]1.[CH:21](Br)([CH3:23])[CH3:22].C(N(CC)CC)C>CN(C=O)C>[F:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([CH3:13])=[CH:7][NH:8][C:9]2=[O:12])=[CH:4][C:3]=1[O:14][CH:15]1[CH2:16][CH2:17][N:18]([CH:21]([CH3:23])[CH3:22])[CH2:19][CH2:20]1

Participants

5

Reactant 3

HCID 63582-BromopropaneHCID 8471TriethylamineHCID 57652410HCID 57652410, compound

Product 1

HCID 57652506HCID 57652506, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

By alkylation of 50 mg of 7-fluoro-4-methyl-6-(piperidin-4-yloxy)-2H-isoquinolin-1-one (22) with isopropylbromide in the presence of triethylamine in DMF at 60° C. 31 mg of 7-Fluoro-6-(1-isopropyl-piperidin-4-yloxy)-4-methyl-2H-isoquinolin-1-one were obtained.

Workup

  1. customat 60° C

Sources & evidence

ORD record
ord-387b10ac33754b46b3a0c932ff6ff8bd
Source dataset
uspto-grants-2012_05
Patent number
US08188117B2

Reaction notes

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