反应详情

温度

90 °C

A mixture of 4-methoxybenzaldehyde (30.0 g, 0.22 mol), phenylacetic acid (31.5 g, 0.23 mol), and triethylamine (31 ml) in acetic anhydride (75 ml) was heated at 90° C. for 5 hours. After cooling, 18 ml of water was dropped carefully during 15 min. Then, potassium carbonate (243 g) in water (1800 ml) was dropped and the solution was heated at 60° C. for 1 hour. After cooling, the solution was extracted with dichloro-methane. When the aqueous phase was acidified (pH 6-7), the product was precipitated. After stirring at 0° C., the product was filtered and dried.

1. temperatureAfter cooling
2. temperaturethe solution was heated at 60° C. for 1 hour
3. temperatureAfter cooling
4. extractionthe solution was extracted with dichloro-methane
5. customthe product was precipitated
6. filtrationthe product was filtered
7. customdried