Tetrahydrofuran → 3-{6-Chloro-2-fluoro-3-[4-(4-methyl-piperazin-1-yl)-4-oxo-butyl]-benzyl}-1-cyclohexyl-pyrrolidin-2-one
Reaction equation
[CH2:63]1[O:64][CH2:65][CH2:66][CH2:67]1.[CH3:28][CH2:29][N:30]=[C:31]=[N:32][CH2:33][CH2:34][CH2:35][N:36]([CH3:37])[CH3:38].[CH3:49][CH2:50][N:51]([CH2:52][CH3:53])[CH2:54][CH3:55].[CH3:56][N:57]1[CH2:58][CH2:59][NH:60][CH2:61][CH2:62]1.[Cl:1][c:2]1[c:3]([CH2:15][CH:16]2[C:17](=[O:27])[N:18]([CH:21]3[CH2:22][CH2:23][CH2:24][CH2:25][CH2:26]3)[CH2:19][CH2:20]2)[c:4]([F:14])[c:5]([CH2:8][CH2:9][CH2:10][C:11](=[O:12])[OH:13])[cH:6][cH:7]1.[OH:39][n:40]1[c:41]2[c:42]([cH:43][cH:44][cH:45][cH:46]2)[n:47][n:48]1>>[Cl:1][c:2]1[c:3]([CH2:15][CH:16]2[C:17](=[O:27])[N:18]([CH:21]3[CH2:22][CH2:23][CH2:24][CH2:25][CH2:26]3)[CH2:19][CH2:20]2)[c:4]([F:14])[c:5]([CH2:8][CH2:9][CH2:10][C:11](=[O:13])[N:60]2[CH2:59][CH2:58][N:57]([CH3:56])[CH2:62][CH2:61]2)[cH:6][cH:7]1Participants
7
Reactant 6
Product 1
Sources & evidence
- ORD record
- ord-924c07c1eb9a48e5bdad27b7af1aeb07
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (6/10)
Reaction notes
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