反应详情

温度

100 °C

To 6-bromo-1-(4-methoxybutyl)-3,3-dimethyl-1,3-dihydro-2H-indol-2-one (1.0 g) were added palladium acetate (207 mg), triphenylphosphine (484 mg), triethylamine (0.86 ml), methanol (0.62 ml), and DMF (10 ml), and the mixture was stirred at 100° C. under carbon monoxide atmosphere for 4 hours. After the reaction was complete, water was added to the reaction solution, and the mixture was extracted with ethyl acetate solution. This ethyl acetate solution was washed with water and an aqueous sodium chloride solution, dried over magnesium sulfate, filtered, and concentrated. The obtained residue was purified by silica gel column chromatography (hexane/ethyl acetate=3/1) to give the title compound (480 mg) as a pale yellow liquid.

1. extractionthe mixture was extracted with ethyl acetate solution
2. washThis ethyl acetate solution was washed with water
3. dry with materialan aqueous sodium chloride solution, dried over magnesium sulfate
4. filtrationfiltered
5. concentrationconcentrated
6. customThe obtained residue was purified by silica gel column chromatography (hexane/ethyl acetate=3/1)