Iodoethane → 2-(2,3-Dichlorophenyl)-3-ethoxy-4-fluoro-2-butenenitrile

HRID 1954931Notes

Reaction equation

HRID 1954931 reaction equation
[Cl:1][C:2]1[C:7]([Cl:8])=[CH:6][CH:5]=[CH:4][C:3]=1[C:9](=[C:12]([OH:15])[CH2:13][F:14])[C:10]#[N:11].[CH2:16](I)[CH3:17].C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O>[Cl:1][C:2]1[C:7]([Cl:8])=[CH:6][CH:5]=[CH:4][C:3]=1[C:9](=[C:12]([O:15][CH2:16][CH3:17])[CH2:13][F:14])[C:10]#[N:11]

Participants

5

Reactant 3

HCID 6340IodoethaneHCID 11430Potassium CarbonateHCID 701862942-(2,3-Dichlorophenyl)-4-fluoro-3-hydroxy-2-butenenitrile

Product 1

HCID 543953282-(2,3-Dichlorophenyl)-3-ethoxy-4-fluoro-2-butenenitrile

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Alkylation of 2-(2,3-dichlorophenyl)-4-fluoro-3-hydroxy-2-butenenitrile can suitably be achieved using ethyl iodide in dimethylformamide in the presence of potassium carbonate to afford crude 2-(2,3-dichlorophenyl)-3-ethoxy-4-fluoro-2-butenenitrile.

Sources & evidence

ORD record
ord-6bda4592dbf4468898c206ced87ecc52
Source dataset
uspto-grants-2000_09
Patent number
US06124308

Reaction notes

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