反应详情

To a solution of 5.00 g Z-Pro-OH in 50 ml DMF were added 3.84 g EDC, 2.73 g HOAt, 7.3 ml DIPEA and 2.2 ml benzylamine at 0° C. After stirring for 2 h the reaction mixture was concentrated, the residue was dissolved in dichloromethane and subsequently extracted with aqueous LiCl (4%), 0.1 M HCl and saturated NaHCO3. The crude product obtained after evaporation of the solvent was pure enough for the subsequent transformation.

1. concentrationwas concentrated
2. dissolutionthe residue was dissolved in dichloromethane
3. extractionsubsequently extracted with aqueous LiCl (4%), 0.1 M HCl and saturated NaHCO3