反应详情

Example 145D can be processed as in Lindley (Tetrahedron, 1983, 1433). A solution of Example 145C (1.0 mmol) and DMF (2.0 mL) is treated at 0° C. with sodium hydride (1.0 mmol), slowly warmed to room temperature, treated with 1-chloro-4-iodobenzene (1.0 mmol) and copper iodide (0.1 mmol), heated at 80° C. overnight, and cooled. The solution is poured into water and extracted with diethyl ether. The extracts are combined, dried (MgSO4), filtered, and concentrated. Recrystallization from ethyl acetate/hexanes provides the title compound.

1. temperatureheated at 80° C. overnight
2. temperaturecooled
3. extractionextracted with diethyl ether
4. dry with materialdried (MgSO4)
5. filtrationfiltered
6. concentrationconcentrated
7. customRecrystallization from ethyl acetate/hexanes