1-Octanethiol → HCID 13362815, compound

HRID 1979527Notes

Reaction equation

HRID 1979527 reaction equation
[NH2:1][C:2]1[C:7]([C:8]([O:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH3:18])=[O:9])=[N:6][C:5]([Cl:19])=[C:4](Cl)[N:3]=1.[CH2:21]([SH:29])[CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH3:28].C(N(CC)CC)C>CN(C)C=O.ClCCl>[NH2:1][C:2]1[C:7]([C:8]([O:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH3:18])=[O:9])=[N:6][C:5]([Cl:19])=[C:4]([S:29][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH3:28])[N:3]=1

Participants

6

Reactant 3

HCID 81441-OctanethiolHCID 8471TriethylamineHCID 13362814HCID 13362814, compound

Product 1

HCID 13362815HCID 13362815, compound

Reagents, catalysts & solvents 2

HCID 6228DimethylformamideSolventHCID 6344DichloromethaneSolvent

Procedure

In 1 ml of dimethylformamide there was mixed n-octyl (2-amino-5,6-dichloropyrazinyl)formate (100 mg; 0.312 mol), prepared in Step B above, and n-octyl thiol (150 mg; 0.936 mol), after which there was added triethylamine (70 mg; 0.624 mol), and the reaction mixture was stirred for 1 hour at room temperature. The reaction mixture was taken up in dichloromethane and passed through a silica gel column to give the title compound. Elemental Analysis:

Sources & evidence

ORD record
ord-2b90fd53b1c54e96b6653f1018f60392
Source dataset
uspto-grants-1984_11
Patent number
US04481202

Reaction notes

Loading…