Sodium Iodide → HCID 68908797, compound

HRID 1986807Notes

Reaction equation

[CH2:1]([CH:6]1[CH2:12][CH:11]2[NH:13][CH:8]([CH2:9][CH2:10]2)[CH2:7]1)[CH2:2][CH2:3][CH2:4][CH3:5].[Na+].[I-].C([O-])([O-])=O.[K+].[K+].[CH3:22][N:23]([CH:25]=[O:26])[CH3:24]>>[CH3:8][C@H:9]([CH2:10][N:13]1[CH:11]2[CH2:10][CH2:9][C@H:8]1[CH2:7][CH:6]([CH2:1][CH2:2][CH2:3][CH2:4][CH3:5])[CH2:12]2)[CH2:22][N:23]1[C:24]2[C:3](=[CH:2][CH:1]=[CH:6][CH:7]=2)[CH2:4][CH2:5][C:25]1=[O:26]

Participants

Reactant 4

HCID 5238Sodium Iodide

HCID 6228Dimethylformamide

HCID 11430Potassium Carbonate

HCID 219898523-Pentyl-8-azabicyclo[3.2.1]octane

Product 1

HCID 68908797HCID 68908797, compound

Procedure

Crude (R,S)-1-(3-chloro-2-methylpropyl)-3,4-dihydro-1H-quinolin-2-one (107LH63) (0.094 g), 3-pentyl-8-azabicyclo[3.2.1]octane (0.027 g, 0.15 mmol), NaI (0.100 g, 0.67 mmol), and K2CO3 (0.075 g, 0.54 mmol) in DMF (1 mL) were reacted and purified according to GP20 to give the title compound (107LH74-c5) (0.023 g). HPLC-MS (ammonium acetate) [M+H]+=383.34.

Workup

custompurified

Sources & evidence

ORD record: ord-fa7e939afde247bcad7839c438d6a8b1
Source dataset: uspto-grants-2009_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07550459B2

Reaction notes

Loading…