Iodoethane → 3-Ethoxy-4,5-dihydroxybenzaldehyde

HRID 1990842Notes

Reaction equation

HRID 1990842 reaction equation
[OH:1][C:2]1[CH:3]=[C:4]([CH:7]=[C:8]([OH:11])[C:9]=1[OH:10])[CH:5]=[O:6].[CH2:12](I)[CH3:13].C([O-])([O-])=O.[K+].[K+]>CN(C=O)C>[CH2:12]([O:1][C:2]1[CH:3]=[C:4]([CH:7]=[C:8]([OH:11])[C:9]=1[OH:10])[CH:5]=[O:6])[CH3:13]

Participants

5

Reactant 3

HCID 6340IodoethaneHCID 11430Potassium CarbonateHCID 836513,4,5-Trihydroxybenzaldehyde

Product 1

HCID 130174903-Ethoxy-4,5-dihydroxybenzaldehyde

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

The title compound was prepared analogously to intermediate 2 (4-methoxy-3-propoxy-benzaldehyde) by reaction of 3,4,5-trihydroxybenzaldehyde with ethyl iodide in DMF using K2CO3 as base. MS (ISN): 181.1 [M−H]−.

Sources & evidence

ORD record
ord-1e6d564eb9da4ed9a64a578b8b18448d
Source dataset
uspto-grants-2010_01
Patent number
US07645753B2

Reaction notes

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