Tert-Butyl isocyanide → HCID 178440949, compound

HRID 2001429Notes

Reaction equation

HRID 2001429 reaction equation
Br[Zn][CH2:1][CH2:2][c:3]1[cH:8][cH:7][cH:6][cH:5][cH:4]1.[CH3:9][C:10]([N+:13]#[C-:14])([CH3:12])[CH3:11]>>[CH3:12][C:9]([c:10]1[n:13][cH:14]c(C(C([CH2:1][CH2:2][c:3]2[cH:8][cH:7][cH:6][cH:5][cH:4]2)=O)=O)c[cH:11]1)(C)C

Participants

9

Reactant 2

HCID 23577Tert-Butyl isocyanideHCID 178419779HCID 178419779, compound

Product 1

HCID 178440949HCID 178440949, compound

Reagents, catalysts & solvents 6

HCID 313Hydrochloric AcidReagentHCID 8471TriethylamineReagentHCID 167845palladium(II) acetateCatalystHCID 24721398Bis(cyclopentyl(diphenyl)phosphane);ironCatalystHCID 1140TolueneSolventHCID 117669-PhenylanthraceneInternal standard

Conditions

Temperature
110 °C

Sources & evidence

ORD record
ord-0ab637ca0821472fb1b9b33046b5497f
Source dataset
39k HTE dataset from Pfizer
Original link
View source

Reaction notes

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