Hydroxyamine hydrochloride → HCID 178433336, compound

HRID 2002642Notes

Reaction equation

HRID 2002642 reaction equation

Cl.[NH2:1][OH:2].[CH3:3][CH:4]([N:6]1[c:18]([c:11]2[CH:10]=[C:9](Br)[C:7]1=[O:8])[n:17][c:15]([NH2:16])[n:14][c:12]2[CH3:13])[CH3:5]>>[CH3:3][CH:4]([N:6]1[c:18]([c:11]2[CH:10]=[C:9](C([NH2:1])=[O:2])[C:7]1=[O:8])[n:17][c:15]([NH2:16])[n:14][c:12]2[CH3:13])[CH3:5]

Participants

8

Reactant 2

HCID 443297Hydroxyamine hydrochloride

HCID 57606978HCID 57606978, compound

Product 1

HCID 178433336HCID 178433336, compound

Reagents, catalysts & solvents 5

HCID 81531DiisopropylethylamineReagent

HCID 167845palladium(II) acetateCatalyst

HCID 117064351(R)-1-[(S)-2-(Dicyclohexylphosphino)ferrocenyl]ethyli-tert-butylphosphineCatalyst

HCID 6342AcetonitrileSolvent

HCID 117669-PhenylanthraceneInternal standard

Conditions

Temperature: 90 °C

Sources & evidence

ORD record: ord-d7ef21b5a73a40c889328ea7473ce87e
Source dataset: 39k HTE dataset from Pfizer
DOI: 10.1038/s41557
Original link: View source

Reaction notes

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