2-(Bromomethyl)pyridine hydrobromide → 2-pyridin-2-yl-N-[5-[[(1S,3R)-3-[5-[(2-pyridin-2-ylacetyl)amino]-1,3,4-thiadiazol-2-yl]cyclopentyl]methyl]-1,3,4-thiadiazol-2-yl]acetamide
Reaction equation
Br.Br[CH2:1][c:2]1[n:7][cH:6][cH:5][cH:4][cH:3]1.[NH2:8][c:9]1[s:25][c:12]([CH2:13][C@@H:14]2[CH2:18][C@H:17]([c:19]3[s:24][c:22]([NH2:23])[n:21][n:20]3)[CH2:16][CH2:15]2)[n:11][n:10]1>>O=C([NH:8][c:9]1[s:25][c:12]([CH2:13][C@@H:14]2[CH2:18][C@H:17]([c:19]3[s:24][c:22]([NH:23]C(Cc4ncccc4)=O)[n:21][n:20]3)[CH2:16][CH2:15]2)[n:11][n:10]1)[CH2:1][c:2]5[n:7][cH:6][cH:5][cH:4][cH:3]5Participants
8
Reactant 2
Product 1
Reagents, catalysts & solvents 5
Conditions
- Temperature
- 110 °C
Sources & evidence
- ORD record
- ord-0cfedd2ac89040c1b3cabedb6164064a
- Source dataset
- 39k HTE dataset from Pfizer
- Original link
- View source
Reaction notes
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