2,2,2-Trifluoroethylamine hydrochloride → HCID 178510507, compound

HRID 2003131Notes

Reaction equation

HRID 2003131 reaction equation
Cl[c:1]1[n:13][c:12]([N:14]2[CH2:19][CH2:18][CH:17]([c:20]3[c:28]([c:23]4[nH:22][n:21]3)[cH:27][cH:26][cH:25][n:24]4)[CH2:16][CH2:15]2)[n:11][c:3]([O:4][CH2:5][C:6]5([C:9]#[N:10])[CH2:8][CH2:7]5)[n:2]1.Cl.[NH2:29][CH2:30][C:31]([F:34])([F:33])[F:32]>>[F:32][C:31]([CH2:30][NH:29]C([c:1]1[n:13][c:12]([N:14]2[CH2:19][CH2:18][CH:17]([c:20]3[c:28]([c:23]4[nH:22][n:21]3)[cH:27][cH:26][cH:25][n:24]4)[CH2:16][CH2:15]2)[n:11][c:3]([O:4][CH2:5][C:6]5([C:9]#[N:10])[CH2:8][CH2:7]5)[n:2]1)=O)([F:34])[F:33]

Participants

7

Reactant 2

HCID 97722,2,2-Trifluoroethylamine hydrochlorideHCID 178510506HCID 178510506, compound

Product 1

HCID 178510507HCID 178510507, compound

Reagents, catalysts & solvents 4

HCID 81531DiisopropylethylamineReagentHCID 167845palladium(II) acetateCatalystHCID 31374DimethylacetamideSolventHCID 117669-PhenylanthraceneInternal standard

Conditions

Temperature
120 °C

Sources & evidence

ORD record
ord-06d4b2e2f64746edb7083dfb08eb25e5
Source dataset
39k HTE dataset from Pfizer
Original link
View source

Reaction notes

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