6-Bromoquinoline → Quinoline-6-sulfonic acid

HRID 2012715Notes

Reaction equation

HRID 2012715 reaction equation
Br[c:1]1[cH:10][c:9]([c:4]2[cH:3][cH:2]1)[cH:8][cH:7][cH:6][n:5]2.CC(Nc1ccc(N(S(F)(=O)=O)[S:12](F)(=[O:14])=[O:13])cc1)=[O:11]>>[OH:11][S:12]([c:1]1[cH:10][c:9]([c:4]2[cH:3][cH:2]1)[cH:8][cH:7][cH:6][n:5]2)(=[O:14])=[O:13]

Participants

8

Reactant 2

HCID 792436-BromoquinolineHCID 1362129244-(Acetylamino)phenyl]imidodisulfuryl difluoride

Product 1

HCID 316975Quinoline-6-sulfonic acid

Reagents, catalysts & solvents 5

HCID 62657Potassium Phosphate, TribasicReagentHCID 167845palladium(II) acetateCatalystHCID 6360441,1'-(9,9-Dimethyl-9H-xanthene-4,5-diyl)bis(1,1-diphenylphosphine)CatalystHCID 8028TetrahydrofuranSolventHCID 117669-PhenylanthraceneInternal standard

Conditions

Temperature
80 °C

Sources & evidence

ORD record
ord-b700865e8ec5450eb06e80747d4c4b34
Source dataset
39k HTE dataset from Pfizer
Original link
View source

Reaction notes

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