1-Methylimidazole → HCID 178480578, compound

HRID 2013722Notes

Reaction equation

HRID 2013722 reaction equation
[CH3:1][n:2]1[cH:6][n:5][cH:4][cH:3]1.[CH3:7][C:8]([O:11][C:12]([N:14]1[CH2:28][CH2:27][CH:17]([CH2:18][O:19][c:20]2[c:25]([NH2:26])[n:24][cH:23][c:22](Br)[cH:21]2)[CH2:16][CH2:15]1)=[O:13])([CH3:10])[CH3:9]>>[CH3:1][n:2]1[c:6]([c:22]2[cH:21][c:20]([O:19][CH2:18][CH:17]3[CH2:27][CH2:28][N:14]([C:12]([O:11][C:8]([CH3:10])([CH3:9])[CH3:7])=[O:13])[CH2:15][CH2:16]3)[c:25]([NH2:26])[n:24][cH:23]2)[n:5][cH:4][cH:3]1

Participants

8

Reactant 2

HCID 13901-MethylimidazoleHCID 121409255Tert-butyl 4-{[(2-amino-5-bromopyridin-3-yl)oxy]methyl}piperidine-1-carboxylate

Product 1

HCID 178480578HCID 178480578, compound

Reagents, catalysts & solvents 5

HCID 23702041Potassium acetate hydrateReagentHCID 167845palladium(II) acetateCatalystHCID 6360441,1'-(9,9-Dimethyl-9H-xanthene-4,5-diyl)bis(1,1-diphenylphosphine)CatalystHCID 31374DimethylacetamideSolventHCID 117669-PhenylanthraceneInternal standard

Conditions

Temperature
110 °C

Sources & evidence

ORD record
ord-3bcee9e346b6416fa294fe558f2e75a9
Source dataset
39k HTE dataset from Pfizer
Original link
View source

Reaction notes

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