Quinoline-3-boronic acid → HCID 178421590, compound

HRID 2016878Notes

Reaction equation

HRID 2016878 reaction equation

[CH3:1][C@@:2]1([c:9]2[c:14]([OH:15])[n:13][c:12](Cl)[cH:11][cH:10]2)[C:7](=[O:8])[NH:6][CH2:5][CH2:4][CH2:3]1.OB([c:16]1[cH:25][c:24]([c:19]2[n:18][cH:17]1)[cH:23][cH:22][cH:21][cH:20]2)O>>[CH3:1][C@@:2]1([c:9]2[c:14]([OH:15])[n:13][c:12]([c:16]3[cH:25][c:24]([c:19]4[n:18][cH:17]3)[cH:23][cH:22][cH:21][cH:20]4)[cH:11][cH:10]2)[C:7](=[O:8])[NH:6][CH2:5][CH2:4][CH2:3]1

Participants

8

Reactant 2

HCID 2734663Quinoline-3-boronic acid

HCID 178421611HCID 178421611, compound

Product 1

HCID 178421590HCID 178421590, compound

Reagents, catalysts & solvents 5

HCID 11430Potassium CarbonateReagent

HCID 741954,4'-Bis(1,1-dimethylethyl)-1,1'-biphenylReagent

HCID 6102075Dichlorobis(triphenylphosphine)palladiumCatalyst

HCID 1140TolueneSolvent

HCID 117669-PhenylanthraceneInternal standard

Conditions

Temperature: 80 °C

Sources & evidence

ORD record: ord-1974464f1da945508eb98a4131ba1b88
Source dataset: 39k HTE dataset from Pfizer
DOI: 10.1038/s41557
Original link: View source

Reaction notes

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