2-Bromopyridine → HCID 178480799, compound

HRID 2018506Notes

Reaction equation

HRID 2018506 reaction equation
[CH3:1][N:2]([C:24]([O:26][C:27]([CH3:30])([CH3:29])[CH3:28])=[O:25])[C@H:3]1[CH2:6][C@H:5]([O:7][c:8]2[c:23]([c:19]3[n:18][c:10]([NH:11][c:12]4[cH:17][n:15]([CH3:16])[n:14][cH:13]4)[n:9]2)[cH:22][cH:21][nH:20]3)[CH2:4]1.Br[c:31]1[n:36][cH:35][cH:34][cH:33][cH:32]1>>[CH3:1][N:2]([C:24]([O:26][C:27]([CH3:30])([CH3:29])[CH3:28])=[O:25])[C@H:3]1[CH2:6][C@H:5]([O:7][c:8]2[c:23]([c:19]3[n:18][c:10]([NH:11][c:12]4[cH:17][n:15]([CH3:16])[n:14][cH:13]4)[n:9]2)[c:22]([c:31]5[n:36][cH:35][cH:34][cH:33][cH:32]5)[cH:21][nH:20]3)[CH2:4]1

Participants

8

Reactant 2

HCID 79732-BromopyridineHCID 178480802HCID 178480802, compound

Product 1

HCID 178480799HCID 178480799, compound

Reagents, catalysts & solvents 5

HCID 517045Sodium AcetateReagentHCID 167845palladium(II) acetateCatalystHCID 6360441,1'-(9,9-Dimethyl-9H-xanthene-4,5-diyl)bis(1,1-diphenylphosphine)CatalystHCID 64052-Methyl-2-butanolSolventHCID 117669-PhenylanthraceneInternal standard

Conditions

Temperature
90 °C

Sources & evidence

ORD record
ord-308dc3a75ee04c37bc49b038589955bf
Source dataset
39k HTE dataset from Pfizer
Original link
View source

Reaction notes

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