2-Bromopyridine → HCID 178480659, compound

HRID 2018552Notes

Reaction equation

HRID 2018552 reaction equation
Br[c:1]1[n:6][cH:5][cH:4][cH:3][cH:2]1.[CH3:7][N:8]([C:38]([O:40][C:41]([CH3:44])([CH3:43])[CH3:42])=[O:39])[C@H:9]1[CH2:12][C@H:11]([O:13][c:14]2[c:26]3[c:25]([n:29]([CH2:30][O:31][CH2:32][CH2:33][Si:34]([CH3:37])([CH3:36])[CH3:35])[cH:28][cH:27]3)[n:24][c:16]([NH:17][c:18]4[cH:23][n:21]([CH3:22])[n:20][cH:19]4)[n:15]2)[CH2:10]1>>[CH3:7][N:8]([C:38]([O:40][C:41]([CH3:44])([CH3:43])[CH3:42])=[O:39])[C@H:9]1[CH2:12][C@H:11]([O:13][c:14]2[c:26]3[c:25]([n:29]([CH2:30][O:31][CH2:32][CH2:33][Si:34]([CH3:37])([CH3:36])[CH3:35])[cH:28][cH:27]3)[n:24][c:16]([N:17]([c:1]4[n:6][cH:5][cH:4][cH:3][cH:2]4)[c:18]5[cH:23][n:21]([CH3:22])[n:20][cH:19]5)[n:15]2)[CH2:10]1

Participants

8

Reactant 2

HCID 79732-BromopyridineHCID 178480801HCID 178480801, compound

Product 1

HCID 178480659HCID 178480659, compound

Reagents, catalysts & solvents 5

HCID 2733832Lithium HexamethyldisilazideReagentHCID 167845palladium(II) acetateCatalystHCID 117064364Ferrocene, 1-[bis[3,5-bis(trifluoromethyl)phenyl]phosphino]-2-[(1R)-1-(dicyclohexylphosphino)ethyl]-, (1R)-CatalystHCID 1140TolueneSolventHCID 117669-PhenylanthraceneInternal standard

Conditions

Temperature
90 °C

Sources & evidence

ORD record
ord-1de7cb53372644a8bb9b57a030e8d31f
Source dataset
39k HTE dataset from Pfizer
Original link
View source

Reaction notes

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