Cis-2-boc-hexahydropyrrolo[3,4-C]pyrrole → HCID 178480791, compound

HRID 2018603Notes

Reaction equation

HRID 2018603 reaction equation
[CH3:1][n:2]1[n:16][cH:15][c:4]([NH:5][c:6]2[c:14]([c:10]3[n:9][c:8](Cl)[n:7]2)[n:13][cH:12][nH:11]3)[cH:3]1.[CH3:17][C:18]([O:21][C:22]([N:24]1[CH2:31][C@@H:30]([C@H:26]2[CH2:25]1)[CH2:29][NH:28][CH2:27]2)=[O:23])([CH3:20])[CH3:19]>>[CH3:1][n:2]1[n:16][cH:15][c:4]([NH:5][c:6]2[c:14]([c:10]3[n:9][c:8]([N:28]4[CH2:27][C@@H:26]([C@H:30]5[CH2:29]4)[CH2:25][N:24]([C:22]([O:21][C:18]([CH3:20])([CH3:19])[CH3:17])=[O:23])[CH2:31]5)[n:7]2)[n:13][cH:12][nH:11]3)[cH:3]1

Participants

8

Reactant 2

HCID 1514452Cis-2-boc-hexahydropyrrolo[3,4-C]pyrroleHCID 178480784HCID 178480784, compound

Product 1

HCID 178480791HCID 178480791, compound

Reagents, catalysts & solvents 5

HCID 2733832Lithium HexamethyldisilazideReagentHCID 167845palladium(II) acetateCatalystHCID 134128718cyclopentane;dicyclohexyl-[2-[(1R)-1-diphenylphosphanylethyl]cyclopentyl]phosphane;ironCatalystHCID 8028TetrahydrofuranSolventHCID 117669-PhenylanthraceneInternal standard

Conditions

Temperature
100 °C

Sources & evidence

ORD record
ord-1e13d61c4da54808adefc3d45b03ab0d
Source dataset
39k HTE dataset from Pfizer
Original link
View source

Reaction notes

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